Gene Expression Study in Positron Emission Tomography-Positive Abdominal Aortic Aneurysms Identifies CCL18 as a Potential Biomarker for Rupture Risk
نویسندگان
چکیده
منابع مشابه
Gene expression study in positron emission tomography-positive abdominal aortic aneurysms identifies CCL18 as a potential biomarker for rupture risk.
Rupture of abdominal aortic aneurysm (AAA) is a cause of significant mortality and morbidity in aging populations. Uptake of 18-fluorodeoxyglucose (FDG) detected by positron emission tomography (PET) is observed in the wall of 12% of AAA (A+), with most of them being symptomatic. We previously showed that the metabolically active areas displayed adventitial inflammation, medial degeneration and...
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OBJECTIVE The aetiology and early pathophysiological mechanisms of aortic aneurysm formation are still unknown and challenging to study in vivo. Positron emission tomography (PET) is a potentially valuable instrument for non-invasive in vivo pathophysiological studies. No specific tracer to identify the pathophysiological process of aneurysmal dilatation is yet available, however. The aim of th...
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1 Sheffield Vascular Institute, Northern General Hospital, Sheffield S5 7AU, UK 2Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), University College London Medical School, Royal Free Hospital Campus, University College London (UCL), London NW3 2QG, UK 3Divisions of Vascular Surgery, New York University Langone Medical Center, New York, NY 10016, USA 4Division of Vascul...
متن کاملGene Expression Profiling in Abdominal Aortic Aneurysms After Finite Element Rupture Risk Assessment.
PURPOSE To investigate the association between local biomechanical rupture risk calculations from finite element analysis (FEA) and whole-genome profiling of the abdominal aortic aneurysm (AAA) wall to determine if AAA wall regions with highest and lowest estimated rupture risk show different gene expression patterns. METHODS Six patients (mean age 74 years; all men) scheduled for open surger...
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OBJECTIVES Inflammation is critical in the pathogenesis of abdominal aortic aneurysm (AAA) disease. Combined (18)F-fludeoxyglucose ((18)F-FDG) positron emission tomography with computed tomography (PET-CT) and ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) are non-invasive methods of assessing tissue inflammation. The aim of this study was...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2014
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2014.00065